Overview Director, Translational Lead – Renal, Inflammation and Fibrosis At GSK, we pursue bold patient-focused ambitions and integrate science, technology and talent to get ahead of disease. Our R&D aims to discover and deliver vaccines and medicines, focusing on assets with the highest probability of success and impact for patients. This role sits within the RIITU in the RIIRU therapy area and is responsible for end-to-end translational science to inform biomarker strategies from preclinical to launch, enabling earlier and higher-confidence asset decisions and supporting PoM, PoC, and responder population predictions. We are seeking a dynamic leader to contribute to these efforts. Key Responsibilities

Disease Biomarker Strategy Development and Delivery: Partner with Clinical Teams, Research Technologies and Development to identify, prioritize and validate disease-relevant biomarkers, mechanistic/surrogate biomarkers, patient stratification, and differential response prediction; deploy biomarkers into clinical studies and interpret data/results.

Translational Leadership: Provide strategic leadership to develop and execute translational research strategies that support discovery and development of novel therapeutics; evaluate business development opportunities.

Translational Innovation: Evaluate novel techniques and technologies (e.g., spatial transcriptomics) to inform translational initiatives and biomarker development; guide validation of human assays to enhance translation using resources such as the Human Cell Atlas and disease tissue multi-omics data.

Cross-functional Collaboration: Work with Translational, Disease Teams, Genetics & Genomics, biology groups, biomarker platforms, Medicine Development Teams, data science, regulatory affairs, BD, and commercial teams to integrate translational research across the drug development lifecycle.

External Partnerships: Build and maintain collaborations with academic institutions, CROs and other partners to access technologies, reagents, biosamples and biomarker expertise; engage external experts and key opinion leaders.

Matrix Leadership: Mentor and develop the team; manage disease and project resources, budgets and timelines; represent RI Translational Unit at portfolio governance reviews to inform pipeline and investment decisions.

Why you?

Basic Qualifications

Ph.D. in a relevant scientific discipline (e.g., Cell/Molecular Biology, Genetics, Pharmacology, Physical Chemistry or related field).

Extensive experience in translational science and biomarker development, ideally in the pharmaceutical or biotechnology industry.

Recognised translational/biomarker expert with scholarly publications and field contributions.

Experience translating biomarkers in Renal, Inflammation and/or Fibrotic indications.

Experience in clinical trial settings, contributing to clinical study activities and clinical/regulatory documentation oversight.

Knowledge of regulatory requirements, industry standards and compliance in Translational Research and biomarker development/validation.

Broad knowledge of technologies and methods used in translational research.

Proven track record of program decision making through biomarker strategies and translational insights supporting drug progression.

Experience leading/external collaborations and evaluating business development opportunities.

Strong management skills to prioritize multiple objectives and meet timelines with attention to detail and high performance.

Inclusive matrix leadership, ability to foster psychological safety and motivate a team toward shared goals.

Adaptive to a fast-paced, evolving research environment with strong problem-solving and critical-thinking skills.

Preferred Qualifications

Awareness of bioinformatic/computational methods to support integrated analysis of translational and biomarker data sets.

Work Location : This role is based in the United Kingdom or the United States with a hybrid on-site/remote model.

Join us in shaping the future of translational science and making a meaningful impact on patients’ lives.

Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company focused on four therapeutic areas to impact health at scale. We value an environment where people can thrive and where ambition for patients, accountability for impact, and doing the right thing are the foundation of our work.

GSK is an Equal Opportunity Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law.

We support agile working; if flexibility matters to you, discuss opportunities with the hiring team. If you require adjustments to our process to demonstrate your strengths, contact UKRecruitment.Adjustments@gsk.com or 0808 234 4391 (hours 8:30am–12:00 noon, Mon–Fri; hours may vary on bank holidays). If your inquiry is not adjustment-related, please consult the UK Recruitment FAQ guide for answers.

Important notice to Employment businesses/Agencies : GSK does not accept referrals from employment businesses/agencies unless prior written authorization is obtained. This ensures compliance with GSK policies.

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