Senior Director, Head of Marketing, US Kidney - AMKD Vertex is seeking a talented leader to join our US Kidney Business Unit to support our aspirations of bringing inaxaplin, a Phase 3 investigational therapy for APOL1-Mediated Kidney Disease (AMKD), to patients. AMKD is a rapidly progressive form of proteinuric kidney disease that is genetically caused and occurs in people of African ancestry. The Senior Director, Head of Marketing, US Kidney - AMKD leads the AMKD marketing team for the US Kidney Business Unit. The US Kidney Business Unit is preparing for potential commercialization of inaxaplin and also povetacicept an investigational therapeutic being studied for the treatment of Immunoglobulin A nephropathy (IgAN) and other B cell-mediated diseases (this role will focus on inaxaplin and AMKD alone). This role will recruit, develop, and retain a high-performing marketing team, develop the launch strategy, and ensure execution of launch prep activities. Functional marketing oversight spans across HCP, Patient, Unbranded, and Thought Leader Marketing. We are seeking a candidate that has a strong track record in US commercial roles in market development, demonstrated success in coaching teammates, and the ability to thrive in a fast-paced, innovation-focused environment. This role reports to the Vice President of the US Kidney Business Unit and is a key member of the BU leadership team . Key Responsibilities Drives the evolution and implementation of our go-to-market model, cross functionally leading the launch plan to execute against our aspirations of bringing potentially transformative therapies to patients across multiple diseases Builds the marketing team, and coaches the team to deliver exceptional results and operate as a high performing team Leads the brand strategic and tactical plans including the annual planning process and related execution Leads team to create commercialization campaigns including compelling key messages, unbranded disease education and branded patient and HCP campaigns Seeks a deeper understanding of the market landscape through insight generation to best position Vertex therapies for success Drives innovative use of data and technology to deliver with agility, clear evaluation of ROI for all activities Defines performance goals and tracks performance against those goals as we prepare for launch, including leading the cross functional launch readiness team Provides input into forecasting assumptions, both short-term and long-term Maintains a high degree of external focus with significant customer and field team engagement Develops strong partnerships with cross-functional teams to support business goals Collaborates with communications review committee to approve materials for use with customers Manages agency partners and team to ensure on budget and timely deliverables Role models and instills a culture of compliance focused on ethics and integrity in all we do Required Education and Experience Typically requires 12 years of work experience and 5 years of supervisory/management experience, or the equivalent combination of education and experience Additional preferred experiences: Specialty product launch experience Market development experience Kidney experience

Required Skills Experience defining the strategy for a brand or portfolio of products requiring significant market development Ability to oversee generation of insights, and apply those insights to business problems/opportunities Analytical mindset, with demonstrated ability to develop strategy, make strategic recommendations, monitor performance, understand ROI and allocate resources Exceptional working knowledge of market forecasts and relationship of business drivers to revenue Exceptional working knowledge of MS Office applications, including PPT, Excel and Word Experience in pharmaceutical marketing, or closely related field(s) (e.g., pharmaceutical sales, ad agency, etc.) Experience managing teams and individual staff members Pay Range: $225,600 - $338,400 Job Description Vertex is seeking a talented leader to join our US Kidney Business Unit to support our aspirations of bringing inaxaplin, a Phase 3 investigational therapy for APOL1-Mediated Kidney Disease (AMKD), to patients. AMKD is a rapidly progressive form of proteinuric kidney disease that is genetically caused and occurs in people of African ancestry. The Senior Director, Head of Marketing, US Kidney - AMKD leads the AMKD marketing team for the US Kidney Business Unit. The US Kidney Business Unit is preparing for potential commercialization of inaxaplin and also povetacicept an investigational therapeutic being studied for the treatment of Immunoglobulin A nephropathy (IgAN) and other B cell-mediated diseases (this role will focus on inaxaplin and AMKD alone). This role will recruit, develop, and retain a high-performing marketing team, develop the launch strategy, and ensure execution of launch prep activities. Functional marketing oversight spans across HCP, Patient, Unbranded, and Thought Leader Marketing. We are seeking a candidate that has a strong track record in US commercial roles in market development, demonstrated success in coaching teammates, and the ability to thrive in a fast-paced, innovation-focused environment. This role reports to the Vice President of the US Kidney Business Unit and is a key member of the BU leadership team . Key Responsibilities Drives the evolution and implementation of our go-to-market model, cross functionally leading the launch plan to execute against our aspirations of bringing potentially transformative therapies to patients across multiple diseases Builds the marketing team, and coaches the team to deliver exceptional results and operate as a high performing team Leads the brand strategic and tactical plans including the annual planning process and related execution Leads team to create commercialization campaigns including compelling key messages, unbranded disease education and branded patient and HCP campaigns Seeks a deeper understanding of the market landscape through insight generation to best position Vertex therapies for success Drives innovative use of data and technology to deliver with agility, clear evaluation of ROI for all activities Defines performance goals and tracks performance against those goals as we prepare for launch, including leading the cross functional launch readiness team Provides input into forecasting assumptions, both short-term and long-term Maintains a high degree of external focus with significant customer and field team engagement Develops strong partnerships with cross-functional teams to support business goals Collaborates with communications review committee to approve materials for use with customers Manages agency partners and team to ensure on budget and timely deliverables Role models and instills a culture of compliance focused on ethics and integrity in all we do Required Education and Experience Bachelor's degree Typically requires 12 years of work experience and 5 years of supervisory/management experience, or the equivalent combination of education and experience Additional preferred experiences: Specialty product launch experience Market development experience Kidney experience

Required Skills Experience defining the strategy for a brand or portfolio of products requiring significant market development Ability to oversee generation of insights, and apply those insights to business problems/opportunities Analytical mindset, with demonstrated ability to develop strategy, make strategic recommendations, monitor performance, understand ROI and allocate resources Exceptional working knowledge of market forecasts and relationship of business drivers to revenue Exceptional working knowledge of MS Office applications, including PPT, Excel and Word Experience in pharmaceutical marketing, or closely related field(s) (e.g., pharmaceutical sales, ad agency, etc.) Experience managing teams and individual staff members Pay Range: $225,600 - $338,400 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid : work remotely up to two days per week; or select 2. On-Site : work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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